Endocrine Abstracts

Introduction: Unilateral aldosterone hypersecretion can be adequately treated based on the localization by adrenal venous sampling. However, bilateral aldosterone producing adenoma or primary aldosteronism with preclinical Cushing syndrome cannot be treated with simple unilateral adrenalectomy. Diagnosis of intra-adrenal localization of aldosterone hypersecretion is necessary for surgical treatment of these types of primary aldosteronism.Method: From 200...

Background: The higher prevalence of urinary albumin was reported in patients with primary aldosteronism (PA) than those with essential hypertension (EH). It remains to be unclear, although ‘glomerular hyperfiltration (HF)’ was hypothesized as one of the mechanisms of urinary albumin.Objectives: To clarify the risk factor of urinary albumin and the relationship with HF in PA.Methods: 123 patients with PA were treated acco...

Context: 18-Oxocortisol (18-oxoF) is a derivative of cortisol that is produced by aldosterone synthase (CYP11B2). The potential for this steroid, as a biomarker for differentiating patients with aldosterone-producing adenoma (APA) from those with idiopathic hyperaldosteronism (IHA), has not been examined.Objectives: We measured 18-oxoF, aldosterone (A) and cortisol (F) in plasma from adrenal vein sampling (AVS) patients. We compared 18-oxoF and 18-oxoF/F...

18-Oxocortisol (18-oxoF) is a derivative of cortisol (F) that is produced by aldosterone synthase (CYP11B2), and its clinical usefulness has not been clarified. We prospectively measured 18-oxoF, using highly sensitive liquid chromatography-tandem mass spectrometry (LC/MS/MS), in peripheral plasma of patients with primary aldosteronism (PA) who underwent adrenal venous sampling (AVS) to differentiate aldosterone producing adenoma (APA) from bilateral hyperplasia. The study was...

Kisspeptins are the product of the KiSS-1 gene, a metastasis suppressor gene, and play important physiological roles in the hypothalamo-pituitary gonadal axis and reproduction. It was reported that kisspeptin-10 stimulated the aldosterone synthesis in H295R human adrenal cancer cells (Nakamura et al., 2007). However, expression of kisspeptin and its receptor has not been studied in tumor tissues of adrenocortical tumors. The aim of the present study was therefore to clarify ex...